Researchers Discover New Possible Link To Alzheimer’s

June 22, 2008


Researchers have uncovered a new clue to the cause of Alzheimer’s disease. The brains of people with the memory-robbing form of dementia are cluttered with a plaque made up of beta-amyloid, a sticky protein. But there long has been a question whether this is a cause of the disease or a side effect. Also involved are tangles of a protein called tau; some scientists suspect this is the cause.
Now, researchers have caused Alzheimer’s symptoms in rats by injecting them with one particular form of beta-amyloid. Injections with other forms of beta-amyloid did not cause illness, which may explain why some people have beta-amyloid plaque in their brains but do not show disease symptoms.

The findings by a team led by Dr. Ganesh M. Shankar and Dr. Dennis J. Selkoe of Harvard Medical School were reported in Sunday’s online edition of the journal Nature Medicine.

The researchers used extracts from the brains of people who donated their bodies to medicine.

Forms of soluble beta-amyloid containing different numbers of molecules, as well as insoluble cores of the brain plaque, were injected into the brains of mice. There was no detectable effect from the insoluble plaque or the soluble one-molecule or three-molecule forms, the researchers found.

But the two-molecule form of soluble beta-amyloid produced characteristics of Alzheimer’s in the rats, they reported.

Those rats had impaired memory function, especially for newly learned behaviors. When the mouse brains were inspected, the density brain cells was reduced by 47 percent with the beta-amyloid seeming to affect synapses, the connections between cells that are essential for communication between them.

The research, for the first time, showed the effect of a particular type of beta-amyloid in the brain, said Dr. Marcelle Morrison-Bogorad, director of the division of neuroscience at the National Institute on Aging, which helped fund the research.

It was surprising that only one of the three types had an effect, she said in a telephone interview.

Morrison-Bogorad said the findings may help explain the discovery of plaque in the brains of people who do not develop dementia. For some time, doctors have wondered why they find some brains in autopsy that are heavily coated with beta-amyloid, but the person did not have Alzheimer’s.

The answer may lie in the two types of beta-amyloid that did not cause symptoms.

Now, the question is why one has the damaging effect and not others.

“A lot of work needs to be done,” Morrison-Bogorad said. “Nature keeps sending us down paths that look straight at the beginning, but there are a lot of curves before we get to the end.”

Dr. Richard J. Hodes, director of the National Institute on Aging, said that “while more research is needed to replicate and extend these findings, this study has put yet one more piece into place in the puzzle that is Alzheimer’s.”

In addition to the Institute on Aging, the research was funded by Science Foundation Ireland, Wellcome Trust, the McKnight and Ellison foundations and the Lefler Small Grant Fund.

This was originally found @ AssociatedPress.com

iNPLACENEWS

Copyright 2008 The Associated Press. All rights reserved.This material may not be published, broadcast, rewritten, or redistributed.

Advertisements

Teacher Accused of Burning Crosses on Students’ Arms

June 20, 2008

Mount Vernon Middle School teacher John Freshwater preached his Christian beliefs despite complaints by other teachers and administrators. He even went as far as to use a device to burn the image of a cross on students’ arms, according to the report filed by independent investigators, consulting firm H.R. On Call Inc. He taught creationism in his science class and was insubordinate in failing to remove a Bible and other religious materials from his classroom, the report said.

School board members were scheduled to meet Friday afternoon to discuss the findings by the investigators, hired by the district to investigate. The report was released Thursday.

The report comes one week after a family filed a federal lawsuit in Columbus against Freshwater and the school district. The lawsuit claims Freshwater burned a cross on their child’s arm that remained for approximately four weeks using a tool known as a high-frequency generator.

Several students interviewed by investigators described Freshwater, who has been employed by the school district for 21 years, as a great guy. The district’s director of teaching and learning, Lynda Westontold investigators that she had been dealing with complaints about Freshwater for much of her 11-year tenure at the district

Other findings show that Freshwater taught that carbon dating was unreliable to argue against evolution.

iNPLACENEWS


Another Tool For Detectives and Forensics

April 29, 2008

A company in Georgia s trying to replace DNA testsing with a means of finding out much of the same information. It would be a great tool for detectives, forensic experts and the military. No one expects it to replace DNA analysis, and representatives of the company suggest it is not meant to.

The new method analyzes antibodies. Each person has a unique antibody bar code that can be taken from blood, saliva or other bodily fluids. Antibodies are proteins used by the body to fend off viruses or otherwise clean the system.

The scientists say an antibody profile can yield results faster and more cost-affectively and be performed in the field with minimal training. National lab administrators have licensed the technology exclusively to Identity Sciences LLC in Alpharetta, Georgia.

iNPLACENEWS


“Mayor Charged, Bodies Found, Meat Plant Explodes, and Prior knowledge of Bridge Issues”

March 24, 2008

YouTube, Google, Revver, DailyMotion, Blip.tv, Veoh, Crackle, Stupid Videos, Sclipo and Viddler


“Do-overs, Governors’ Affairs, and Collapsed Cranes”

March 18, 2008

YouTube, Google, DailyMotion, Blip.tv, Veoh, Crackle, Stupid Videos, Sclipo and Viddler


“Delegates, Chaos, and Bombs”

March 9, 2008

YouTube, Google, Revver, DailyMotion, Blip.tv, Veoh, Crackle, Stupid Videos, Sclipo and Viddler


Bush Says NO to OIL? WTF??!!

March 5, 2008

YouTube, Revver, DailyMotion, Blip.tv, Veoh, Crackle, Stupid Videos, Sclipo and Viddler